BML-275 Solution (10 mM)

Product Introduction

Background

BML275 is a reversible and selective inhibitor of AMPK that induces autophagy. It is an inhibitor of the BMP type I receptor ALK2/3/6, downregulating BMP signaling activity and promoting neural differentiation in human pluripotent stem cells (hPSC).It reverses autophagy activation and anti-inflammatory effects caused by Urolithin A (HY-100599). BML275 is a selective inhibitor of bone morphogenetic protein (BMP) signaling.
It has been found to inhibit BMP signaling required for embryogenesis and significantly promote neural differentiation of human pluripotent stem cells (hPSC). It also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase).

Ingredient Statement

Matters Need Attention

1. This product was sterilized by 0.1 μm filtration and can be used directly after melting.
2. It is necessary to pay attention to the aseptic operation and avoid the contamination.
3. Before using, the product should be thawed at 2-8℃ and shaken thoroughly

repeated freeze-thaw cycles are not advised.
4. If precipitation happens after thawing, the contents can be resuspended by pipetting or vortex mixing. After incubating the solution at 37℃ for 20 to 30 minutes or letting it stand at room temperature for about an hour, check to see if the precipitate dissolves as intended. If the product dissolves completely, it can be used as usual.
5. This product is a concentrated solution and should be diluted prior to use as required.
6. The product should be used within a month if stored regularly at 2-8℃. Keep in a frozen state at -5~-20℃ for extended storage. Long-term storage at room temperature or between 2-8℃ is not recommended. When lesser amounts are required, aliquoting is advised to prevent repeated freeze-thaw cycles.
7. This product is for research use only.